New drug development dr g a waghmare 21 8 11 1 new drug development dr g a waghmare 21 8 11 1 53 phase 0 microdosing a new approach to obtain human pharmacokinetic information before the usual expensive phase i safety program is conducted is the phase 0 microdosing it is hypothesized that microdosing will help to reduce or replace the . A balanced mix of experts from academia and industry give insight in selected new developments in the drug discovery pathway the topics cover the different parts of the drug discovery process starting with new developments in the target identification and validation area. Two main approaches of systems biology can be distinguished top down systems biology is a method to characterize cells using system wide data originating from the omics in combination with modeling those models are often phenomenological but serve to discover new insights into the molecular network under study. The prevention of arrhythmogenic remodelling sometimes called upstream therapy differs from classical anti arrhythmic drug approaches by targeting the development of the arrhythmic substrate
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